东莞市幽门螺杆菌耐药状况临床研究

目的研究东莞市幽门螺杆菌(H.pylori,Hp)对克拉霉素、阿莫西林、甲硝唑、呋喃唑酮、利福昔明和左氧氟沙星的耐药状况。方法取东莞市因上消化道症状而接受胃镜活检标本163例,进行Hp培养、分离,应用E-test法进行克拉霉素、阿莫西林、甲硝唑、呋喃唑酮、利福昔明和左氧氟沙星的药敏试验。结果克拉霉素的耐药率为27.6%(21/76),阿莫西林的耐药率为6.6%(5/76),甲硝唑的耐药率为89.5%(68/76),呋喃唑酮的耐药率13.2%(10/76),利福昔明的耐药率0,左氧氟沙星的耐药率为9.2%(7/76),甲硝唑和克拉霉素的同时耐药率为14.4%(11/76)。结论东莞市幽门螺杆菌对甲硝唑的耐药率(89.5%)高,对克拉霉素、呋喃唑酮和左氧氟沙星的耐药(27.6%、13.2%、9.2%)有一定的比例,对阿莫西林的耐药菌株(6.6%)也已出现,未见对利福昔明耐药(耐药率为0)。

Objective To study the the resistance to clarithromycin,amoxicillin,metronidazole,furazolidone,rifaximin and levofloxacin of Helicobacter pylori（H.pylori）strains in Dongguan city.Methods The tissue samples were collected by gastroscope biopsy from the outpatients and inpatients with gastric diseases in Dongguan city.H.pylori was cultured from gastric biopsy specimens and the isolated strains were tested for clarithromycin,amoxicillin,metronidazole,furazolidone,rifaximin and levofloxacin resistance by E-test.Results Among 76 H.pylori strains,the resistance rate to clarithromycin was 27.6%（21/76）;to amoxicillin 6.6%（5/76）;to metronidazole 89.5%（68/76）;to furazolidone13.2%（10/76）;to rifaximin 0%;to levofloxacin 9.2%（7/76）;the resistance rate to both metronidazole and clarithromycin were 14.4%（11/76）.Conclusion In Dongguan city,the resistance rate of H.pylori to metronidazole was the highest（89.5%）,and the second was to clarithromycin,furazolidone and levofloxacin（27.6%、13.2%、9.2% respectively）.It is interesting that the H.pylori strain resistant to amoxicillin appeared.There have been no H.pylori strains resistant to rifaximin up to now.