妊娠期糖尿病患者肿瘤坏死因子-和瘦素水平的变化及其意义

Change of tumor necrosis factor-α and leptin levels in gestational diabetes

目的探讨妊娠期糖尿病(GDM)患者血清肿瘤坏死因子-α(TNF-α)及瘦素(LP)水平的变化。方法检测45例GDM孕妇、45名健康孕妇、45名正常非孕妇女血清TNF-α、LP及胰岛素水平,分析TNF-α、LP与胰岛素水平之间关系。结果 GDM患者的血清TNF-α及LP水平均明显高于健康孕妇和非孕妇女(P<0.01),健康孕妇和非孕妇女的TNF-α、胰岛素水平则差异无统计学意义;GDM组TNF-α、LP与胰岛素水平呈正相关(r=0.413、0.738,P<0.05)。结论 GDM患者的血清TNF-α和LP水平增高,这可能是引起GDM发病机制之一。

Objective To observe the change of TNF-α and leptin levels in patients with gestational diabetes.MethodsTNF-α,leptin and insulin levels were detected in 45 gestational diabetics,and 45 healthy pregnant and 45 nonpregnant women,and their relationship was then analyzed.Results TNF-α and leptin levels in gestational diabetics were superior to those in healthy pregnant and nonpregnant women（P0.01）,but there were no differences in TNF-α and insulin levels between healthy pregnant and nonpregnant women.TNF-α and leptin contents were positively correlated with insulin concentration in gestational diabetics（r=0.413,P0.05;r=0.738,P0.05）.Conclusion The increase of serum TNF-α and leptin levels could be involved in the pathogenesis of gestational diabetes.