我院2004-2008年洋葱伯克霍尔德菌耐药性分析

Analysis of antibiotic resistance of Burkholderia cepacia from 2004 to 2008

目的了解我院2004-2008年洋葱伯克霍尔德菌耐药状况,为临床有效治疗洋葱伯克霍尔德菌感染提供帮助。方法从各类标本中分离出洋葱伯克霍尔德菌株,并利用API系统鉴定,采用Kirby-Bauer法和微量肉汤稀释法进行药敏试验。结果共分离出599株洋葱伯克霍尔德菌。该菌的耐药率呈逐年上升趋势,其对哌拉西林/他唑巴坦和米诺环素的耐药率最低,2008年分别为8.6%和11.2%。结论洋葱伯克霍尔德菌作为院内感染的重要致病菌之一,对临床上常用的抗生素高度耐药。哌拉西林/他唑巴坦和米诺环素可作为治疗洋葱伯克霍尔德菌感染的首选。

Objective To investigate the antibiotic resistance of Burkholderia cepacia from 2004 to 2008 and to provide help for the clinical treatment of infection caused by Burkholderia cepacia. Methods Burkholderia cepacia strains were isolated from kinds of specimens and were identified by API system. Antibiotic sensitive test adopted KirbyBauer method and broth microdilution method. Results 599 strains of Burkholderia cepacia were isolated from 2004 to 2008. The resistant rate of Burkholderia cepacia was increasing year by year. The resistant rate to piperacillin-tazobactam and minocycline was lowest（ 8. 6% and 11. 2% respectively） in 2008. Conclusion As the important pathogen of nosocomial infection,Burkholderia cepacia were highly resistant to the drugs that commonly used in clinic. Piperacillin-tazobactam and mnocycline can be used as the first choice in the treatment of Burkholderia cepacia infection.