复方胆通片对肝硬化患者血清球蛋白的影响

Effect of Compound Bile Tablets on serum globulin of patients with liver cirrhosis

目的:观察复方胆通片治疗对肝硬化患者血清球蛋白等的影响。方法:60例乙肝肝硬化患者随机均分为空白组、对照组与实验组,患者均接受抗病毒等常规治疗,对照组加用熊去氧胆酸胶囊,实验组加用复方胆通片治疗。比较治疗4周后三组患者血清球蛋白、白蛋白/球蛋白比值、外周血白细胞计数等的差异。结果:空白组、对照组与实验组治疗前后血清球蛋白分别为(32.24±5.19)g/L与(31.96±5.27)g/L、(32.34±4.98)g/L与(28.06±5.57)g/L、(32.31±5.26)g/L与(27.66±5.86)g/L,治疗后对照组、实验组分别与空白组比较,差异有统计学意义(P<0.05)。三组治疗前后白蛋白/球蛋白比值分别为(1.014±0.206)与(1.029±0.170)、(1.008±0.162)与(1.248±0.244)、(1.011±0.195)与(1.276±0.275),治疗后对照组、实验组分别与空白组比较,差异有统计学意义(P<0.05)。三组治疗前后白细胞计数差异无统计学意义(P>0.05)。结论:复方胆通片能够降低肝硬化患者的血清球蛋白水平,作用与熊去氧胆酸胶囊接近。

Objective： To observe the effects of Compound Bile Tablets on the serum globulin and so on of patients with liver cirrhosis. Methods： 60 patients with liver cirrhosis were randomly divided into blank group, control group and experimental group, all patients received conventional anti-virus treatment, the control group was treated with Ursodeoxycholic Acid, the experimental group was added with Compound Bile Tablets. Compared the serum globulin, white/globulin ratio, peripheral white blood cell count and other differences in three groups after 4 weeks of treatment. Results： The serum globulin of blank group, control group and experimental group before and after treatment were （32.24±5.19） g/L and （31.96±5.27） g/L, （32.34±4.98） g/L and （28.06±5.57） g/L, （32.31±5.26） g/L and （27.66±5.86） g/L, comparison of control group, experimental group and blank group showed significant difference （P〈0.05）. Three groups before and after treatment of white/globulin ratio were （1.014±0.206） and （1.029±0.170）, （1.008±0.162） and （1.248±0.244）, （1.011±0.195） and （1.276± 0.275）, comparison of control group, experimental group and blank group showed significant difference （P〈0.05）. Three groups of white blood cell count before and after treatment had no statistical difference （P〉0.05）. Conclusion： Compound Bile Tablets can reduce the level of serum globulin, the role is close to Ursodeoxycholic Acid.