低分子肝素在经皮冠状动脉成形术中的应用

The application of low-molecular-weight heparins in percutaneous coronary intervention

目的:探讨低分子肝素在经皮冠状动脉介入治疗(PCI)中应用的有效性和安全性。方法:将612例行择期PCI术的患者分为两组,A组为PCI术中常规用普通肝素(UFH),B组为术中用体重校正低分子肝素(LMWH)。结果:A组与B组手术成功率(98.7%与98.0%)、30d内再次血运重建(3例与2例)、30d内主要心血管不良事件(各2例)、急性血栓形成(均为0例)和周围血管并发症(6例与4例)比较,差异均无统计学意义(均P>0.05)。结论:低分子肝素在PCI术中的应用是一种安全、有效的方法。

Objective： To investigate the effectiveness and safety ef low-molecular-weight heparins application in PCI. Methods： 612 PCI patients were divided into two groups, group A used common depo-heparin （UFH）, group B used low-molecular-weight heparins （LMWH）. Results： The success rate of operation （98.7% vs 98.0%）, target vessel revaseularization within 30 days （3 vs 2 patients ）, major adverse cardiovascular event within 30 days （2 patients in both groups）, acute thrombosis （0 in both groups） and peripheral vascular complications （6 vs 4 patients） of the two groups had no significant difference （all P〉0.05）. Conclusion： Low-molecular-weight heparins in pereutaneous coronary intervention is an effective and safe method.