摘要
目的:观察内皮抑素(ES)在妊娠肝内胆汁淤积症(ICP)胎盘中的表达。方法:采用免疫组织化学方法,检测25例正常妊娠胎盘(对照组)和25例ICP胎盘(ICP组)中ES的水平。结果:ES在正常妊娠胎盘和ICP胎盘中分布基本一致,分布在胎盘滋养叶细胞、血管及绒毛间质。ICP组胎盘中ES轻度表达占28%,中度表达占36%,重度表达占36%。而对照组中ES的轻度表达占32%,中度表达占56%,重度表达占12%。ICP组中ES表达明显高于对照组(P<0.01)。结论:ICP胎盘中ES的增加可能与胎盘血管生成减少及胎盘滋养叶细胞侵入异常有关,在ICP发病中占有一定的地位。
Objective：To investigate the expression of endostatin（ES） in placenta from patients with intrahepatic cholestasis of pregnancy（ICP）.Methods：The expression of ES in 25 placentas from normal pregnancy（control group） and 25 placentas from ICP（ICP group） was detected by immunohistochemistry.Results：The distribution of ES in placenta was found similar for both control and ICP groups in villous trophoblast,blood vessels and stroma.Rating ES expression as light,moderate and strong,the incidences were 28%,36% and 36% in ICP group and 32%,56%,and 12% in control group,respectively.The level of ES was significantly higher in ICP group than that in control group（P〈0..01）.Conclusion：The increase of ES in placenta from ICP may be related to inadequate blood vessel formation and abnormal invasion of trophoblast and may play a role in the cause of ICP.
出处
《药学与临床研究》
2010年第4期341-343,共3页
Pharmaceutical and Clinical Research
关键词
妊娠肝内胆汁淤积
胎盘
内皮抑素
Intrahepatic cholestasis of pregnancy
Placenta
Endostatin
