硫酸镁联合盐酸利托君治疗早产胎膜早破的临床研究

目的比较未足月的早产胎膜早破孕妇并发症的发病情况、终止妊娠方式和对围产儿结局的影响;探讨未足月的早产胎膜早破孕妇期待治疗时不同宫缩抑制剂应用延长孕龄与围产儿预后的关系。方法将28～31周PPROM孕妇73例分为两组:A组(硫酸镁组,n=32),B组(硫酸镁加盐酸利托君组,n=41)。对各组间的母儿围产期发病进行观察分析。结果两组母体并发症资料比较无统计学意义,B组潜伏期长于A组,差异有显著性(P<0.05)。围产儿结局A组NRDS、颅内出血显著多于B组,差异有显著性(P<0.05)。A组围产儿死亡显著多于B组,差异有显著性(P<0.05)。结论对未足月的PPROM的处理采取期待治疗并密切监测胎儿宫内状况实施以合适的分娩方式终止妊娠,改善母儿预后,硫酸镁静脉滴注加盐酸利托君口服保胎效果优于单纯硫酸镁静脉滴注,值得推广。

Objective To compare the incidence of maternal complications,mode of termination of pregnancy and perinatal outcomes of the premature rupture of membranes remote from term ;discuss the relationship between premature rupture of membranes from pregnant women during different expectant Palace inhibitors reduce application to extend the gestational age and perinatal prognosis.Methods 73 patients 28-31 weeks of PPROM pregnant women were divided into 2 groups：group A（magnesium group,n=32）,group B（magnesium sulfate Ritodrine hydrochloride group,n=41）.The mother of the children in each group were observed and analyzed perinatal morbidity.Results There were more maternal complications were no significant information,group B incubation period longer than the group A,the difference was significant（P〈0.05）.perinatal outcome NRDS,intracranial hemorrhage of group A were significantly more than group B,the difference was significant（P〈0.05）.Group A of perinatal death were significantly more than group B,the difference was significant（P〈0.05）.Conclusion PPROM away from full-term treatment to expectant management and close monitoring of fetal status of the implementation of an appropriate mode of delivery termination of pregnancy,to improve the prognosis of female children,intravenous infusion of magnesium sulfate oral ritodrine hydrochloride tocolytic effect is superior to intravenous magnesium sulfate in pure,worthy of promotion.