CA_(125)及其半衰期对卵巢癌诊断与监测的评价

Clinical significance of serum CA_(125) and its half-life analysis in dliagnosis and prognosis of ovarian cancer

目的：观察卵巢癌患者血清CA125在该病的早期诊断、鉴别诊断和术后监测中的意义。方法：应用单克隆抗体（mAb）双位点夹心ELISA一步法。结果：检测血清CA125诊断卵巢癌的敏感性、特异性和准确度分别为88．5％，87．3％和87．7％；其中I、II、III和IV期卵巢癌患者血清CA125的阳性率分别为60％，75％，93．3％和100％；术后3个月血清CA125的含量与第2，3次探查术确诊的符合率分别为68．7％和72．7％；CA125的半衰期与第2，3次探查术的符合率分别为100％和90．9％。结论：血清CA125的检测对盆腔包块良恶性的鉴别具有重要的意义。其含量双阳性率与临床分期密切相关；但其半衰期对卵巢癌的复发和术后残存灶的评估优于CA125含量测定。

To evaluate the clinical value of detechon of serum CA125 level and itS halife in early and differential sts and prognosis of ovallan canceL Methods: The double mAb Sandwich ELISA was ed. Results: Uaing 40 u/ml of the cut-off value for malignant ovallan tumor, the sensitivity, specificity and accuracy of the ELISA for detection of sertun CA125 were 88. 5%, 87. 3% and 87. 7%, respeCtively. The posihve rates of serum CA125 detectal in sacs I, II, III and IV of pahents with ovarian cancer were succeSSively 60%, 75%, 93. 3% and 100%. The coincidence rates of serum CA125 level at 3 months after operation with diagnosis condrmed through the second and for exploratory operation respectively were 68. 7% and 72. 7%, and the coincidence rates Of half-life of CA125 with the diagneds were 100% and 90. 6%. Conclusion: Detectioni of serum CAl125 level is of signifecance in dmerentiation between benign and regnant Pelvic masses. Serum CAlf level and its posibye rate are closely related to clinical stages of overman cancer. However, detechon of half-life of CAlfs is better than its serum level for eshmahon Of recurrence of ovarian cancer and its residual foci in vivo.