转录因子FoxO3a相关调控通路研究进展
被引量：3
摘要
Forkhead转录因子的命名，源于果蝇的“叉头”突变，该突变可导致肠的前后部发育缺陷。Forkhead转录因子家族有着一个高度保守的DNA结构域，这个保守序列的共同特征是具有一个长110个氨基酸的DNA结合结构域，即Forkheadbox（Fox）结构域，并折叠成3个α-螺旋（helix1、2、3）和2个翅膀状（winged）的大环结构，从而形成一个“螺旋-转角-螺旋”的基序。由此，根据上述保守DNA结合结构域的特点，义把这类转录因子叫做Forkhead／winged helix转录因子。2000年，Fox基因被正式统一命名为Forkhead转录因子家族。
出处
《老年医学与保健》
CAS
2010年第4期254-257,共4页
Geriatrics & Health Care
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