转录因子FoxO3a相关调控通路研究进展
被引量：3
摘要
Forkhead转录因子的命名，源于果蝇的“叉头”突变，该突变可导致肠的前后部发育缺陷。Forkhead转录因子家族有着一个高度保守的DNA结构域，这个保守序列的共同特征是具有一个长110个氨基酸的DNA结合结构域，即Forkheadbox（Fox）结构域，并折叠成3个α-螺旋（helix1、2、3）和2个翅膀状（winged）的大环结构，从而形成一个“螺旋-转角-螺旋”的基序。由此，根据上述保守DNA结合结构域的特点，义把这类转录因子叫做Forkhead／winged helix转录因子。2000年，Fox基因被正式统一命名为Forkhead转录因子家族。
出处
《老年医学与保健》
CAS
2010年第4期254-257,共4页
Geriatrics & Health Care
参考文献25
-
1Kaesmer KH, Knochel W, Martinez DE. Unified nomenclature for the winged helix/forkhead transcription factors [J]. Genes Dev, 2000, 14 (2): 142-146.
-
2Maiese K, Chong ZZ, Shang YC. "Sly as a FOXO": new paths with Forkhead signaling in the brain [J]. Curr Neurovasc Res, 2007, 4 (4): 295-302.
-
3Abid MR, Yano K, Guo S, et al. Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia [J]. J Biol Chem, 2005, 280 ( 33 ): 29864-29873.
-
4Brunet A, Park J, Tran H, et al. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a) [J]. Mol Cell Biol, 2001, 21 (3): 952-965.
-
5Wu W., Zou M, Brickley DR, et al. Glucocorticoid receptor activation signals through forkhead ranscription factor 3a in breast cancer cells [J]. Mol. Endocrinol, 2006 (20): 2304-2314.
-
6Hu MC, Lee DF, Xia W, et al. KappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a [J]. Cell, 2004 (117): 225-237.
-
7Yang W, Dolloff NG, EI-Deiry WS. ERK and MDM2 prey on FOXO3a [J]. Nat Cell Biol, 2008, 10 (2): 125-126.
-
8Yang JY, Zong CS, Xia W. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation [J]. Nat Cell Biol, 2008, 10 (2): 138-148.
-
9Lee HY, Chung JW, Youn SW, et al. Forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61, leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia [J]. Circ Res, 2007, 100 (3): 372-380.
-
10Fukuoka M, Daitoku H, Hatta M. Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation [J]. IntJMolMed, 2003, 12 (4): 503-508.
同被引文献24
-
1Richard Seonghun Nho,Polla Hergert.FoxO3a and disease progression[J].World Journal of Biological Chemistry,2014,5(3):346-354. 被引量：29
-
2孙强,邱勇.BMPs信号通路调控骨髓间质干细胞的成骨分化[J].临床骨科杂志,2005,8(5):471-474. 被引量：4
-
3Takashi S, Masafi.mli O, Yoshiaki H, et al. Acceleration effect of hu- man recombinant ]one morphogenetic protein-2 on diI;'rentiation of human pulp ('ells into odontoblasts I J ]. Emtodortics, 2004,30 ( 4 ) : 205 - 208.
-
4Ishida W, Hamamoto T, Kusanagi K, et al. Small6 is a Smadl/5-in- duced Smad inhibitor. Characterization of bone morphogenetic protein- responsive element in [tie mouse Smad6 promoter l J j. J Biol Chem, 2000 ,275 ( 9 ) : 6075 6079.
-
5Kaestner KH, Krohel W, MarLinez DE. Unified nomenclature for the winged helix/Ic, rkhead transcription tach)rs [ J ]. Geres De, 2000,14 (2) :142 - 146.
-
6Liu ZL,Castrillon DEl,Zhou W,et al. FOXO1/3 Depletion in granulo- sa cells alters t?llic]e growlh, death and regulalion of pituitary FSH I J ]. Mol Etuhcrino1,2013,27 ( 2 ) :238 - 252.
-
7Urist MR. Bone : formation by actionndaction J ]. Science, 1965,150 ( 698 ) :893 - 899.
-
8Wang Y, Zhou L,(;hen J.Association of the 3'UTR FOXO3a polymorphism rs4946936 with an increased risk of childhood acutelymphoblastie leukemia in a Chinese population[J~. Cell Physiol Biochem, 2014,34(2) : 325-332.
-
9Ozel Turkcu U,Solak Tekin N,Gokdogan Edgunlu T, et. al . The association of Foxo3a gene polymorphisms with serum Foxo3a levels and oxidative stress markers in vitiligo patients [J]. Gene, 2014,536(1) ~ 129-134.
-
10Maiese K, Chong ZZ, Shang YC. "Sly as a FOXO": new paths with Forkhead signaling in the brain E J 1. Curr Neurovasc Res, 2007,4(4) : 295-302.
引证文献3
-
1王云虹,慈浩粟,杨勇.转录因子FOx03a在小鼠牙胚发育过程中的表达[J].潍坊医学院学报,2013,35(5):328-330.
-
2邓霖,王玉霞,商雪莹.FoxO3a基因rs2253310位点多态性与2型糖尿病的相关性[J].山东医药,2015,55(39):13-15. 被引量：1
-
3邓霖,王玉霞,刘畅,赵雨舒,赵阳.辽宁地区FoxO3a基因rs4946936多态性与2型糖尿病的相关性研究[J].医学临床研究,2016,33(3):488-489.
-
1董林,王艳萍,王金良,沈志强.Foxp3的结构、表达调控及在免疫抑制中的功能研究[J].现代免疫学,2011,31(2):164-167. 被引量：4
-
2黄莉莉,邵启祥.Foxp3在免疫系统中的作用研究进展[J].江苏大学学报（医学版）,2007,17(4):361-364.
-
3包新杰,王任直.间充质干细胞的免疫学特性[J].医学研究杂志,2011,40(5):144-147. 被引量：3
-
4包新杰,王任直.间充质干细胞的免疫学特性[J].中华细胞与干细胞杂志（电子版）,2011,1(1):62-64. 被引量：2
-
5尤武林,黄桂成,张亚峰,马勇,王建伟.过表达叉头框转录因子C2促进间充质干细胞成骨分化[J].中华实验外科杂志,2016,33(11):2600-2600.
-
6马宁耶,张淑兰.叉头状/翼状螺旋转录因子3与妇科恶性肿瘤相关性研究进展[J].国际妇产科学杂志,2013,40(3):255-257. 被引量：4
-
7李昌明,肖青,韩建魁.白细胞介素-6的临床应用进展[J].中国误诊学杂志,2007,7(1):30-32. 被引量：22
-
8陈琳,唐三元.miR-200c在肿瘤中的研究进展[J].现代医药卫生,2014,30(18):2781-2783.
-
9季明春,周瑶玺.白细胞介素7(IL-7)的研究概况[J].国外医学（免疫学分册）,1991,14(1):9-12.
-
10叶媛,鲁峰,李青峰,高建华.脂肪来源干细胞和血管基质片段的研究进展[J].中华整形外科杂志,2017,33(2):153-157. 被引量：12
