丙型肝炎治疗的多因素分析

ANALYSIS FOR THE TREATMENT OF HEPATITIS C BY MULTIPLE STEPWISE REGRESSION

目的探讨丙型肝炎患者的治疗及预后。方法对收治的８７例患者进行多因素分析。结果总有效率为６６．６７％，无应答和恶化占３３．３３％。有明确血清暴露史的预后较好，可能与病史明确，病程较短有关。并发其它慢性疾病者疗效较差，与机体既往健康状况有关。干扰素治疗有效，且与疗程呈正相关。结论建议有输血等血清暴露史者，应定期检测血清ＨＣＶ标志物，以便及时发现ＨＣＶ感染，早期使用干扰素，效果较好。

ObjectiveTo analyze the affecting factors on the treatment of hepatitis C.MethodsSeven variates (sex,age, clinical courses,etc.included)on the treatment of hepatitis C were analysed with multiple regression analysis.ResultsThe total clinical efficacy rate was 66.6 % (58/87) in the series. The clinical treatment was more effective in the cases with sero exposure than those without sero exposure.The reason for the difference may be the relatively short history of HCV infection.Failure in the treatment was usually found in the patients complicated with other diseases such as diabetes,heart or brain diseases and malignant tumor etc. Interferon was effective in the treatment of hepatitis C and its treating was related with the course of treatment. ConclusionIt is suggested that the marker of HCV should be examined in the patients with sero exposure,so that the infection of HCV is found in time,and the treatment is more effective in the patients in which the interferon was used earlier.