不同剂量米非司酮与MTX联合治疗未破裂型异位妊娠的临床观察

Clinical Observation of Unruptured Ectopic Pregnancy Treated by Mifepristone and MTX

目的探讨不同剂量米非司酮与MTX联合治疗未破裂型异位妊娠的临床效果。方法回顾性分析2005年3月至2009年8月在南湾人民医院采用不同保守治疗方案的未破裂型异位妊娠患者156例,总结分析不同剂量米非司酮与MTX联合治疗的保守治疗效果。结果较大剂量米非司酮联合治疗组的治愈率明显高于小剂量米非司酮联合治疗及单一用MTX治疗两组,比较差异具有统计学意义(P<0.01),小剂量米非司酮联合治疗组的治愈率高于单一用MTX治疗组,比较差异具有统计学意义(P<0.05),药物不良反应方面,MTX剂量加大具有骨髓抑制作用,而加大米非司酮剂量在不良反应方面无显著差异,比较差异无统计学意义(P>0.05)。结论较大剂量米非司酮与MTX联合治疗未破裂型异位妊娠,可有效提高疗效,且不增加药物不良反应。

Objective To explore effect of different doses of mifepristone combined with MTX treatment of unruptured ectopic pregnancy.Method Retrospective analysis from March 2005 to August 2009 in Nanwan hospital from different conservative treatment programs in patients with un-ruptured ectopic pregnancy 156 cases,Summary analysis of different doses of mifepristone and MTX combination therapy of conservative treatment.Result Larger doses of mifepristone combined treatment group of cure rate is significantly higher than small doses combined treatment and single use MTX therapy two groups,Comparison difference statistically significance（P0.01）,Small doses of mifepristone treatment,the cure rates higher than the single treatment group with MTX,Comparison difference statistically significance（P0.05）,About drug side effects,MTX dose increases with bone marrow suppression,Increase the dose of mifepristone was no significant difference in side effects,No statistical significance（P0.05）.Conclusion Larger doses of mifepristone combined with MTX treatment of unruptured ectopic pregnancy,can effectively improve effectiveness,and does not increase adverse drug reactions.