高效液相色谱测定化妆品中的紫外线吸收剂

Determination of UV Absorbers in Cosmetic by HPLC

研究了用甲醇－四氢呋喃－水作为流动相，从Ｃ１８柱上分离和测定羟苯甲酮－５－磺酸（ＭＳ４０）、水杨酸钠、水杨酸苯酯（Ｓａｌｏｌ）、羟苯甲酮（Ｍ４０）、对－二甲酸氨基苯甲酸－２－乙基己酯（６００７）、４－叔丁基－４－甲氧基二苯甲酸甲烷（１７８９）、对－甲氧基肉桂酸－２－乙基己酯（ＭＣＸ）、水氧酸－２－乙基己酯（５８７）等８种紫外线吸收剂的色谱条件，建立了用ＨＰＬＣ测定上述物质的方法。其保留时间从２．８３ｍｉｎ（ＭＳ４０）到１５．８９ｍｉｎ（５８７）之间，回收率为９６．１％～１００．６％，相关系数ｒ≥０．９９９５。

The charomatographic conditions of separation and direct dermination of benzophenone-4(MS40), salizyle acid sodium, salol, benzophenone-3(M40), octyl dimethyl PABA(6007), butyl methoxy dibenzoyl methane(1789), octyl methoxyl cinnamate(MCX) and octyl salicylate(587) from u-Bondapak C18 Column were studied with methanol-water-THF as elution. A HPLC method for these compounds was founded. The retention time was from 2.83 min(M40) to 15.89 min(587), the recovery rate was 96.1%～100.6%, and the linearity was r≥0.999 5.