摘要
Objective： To observe the effects of moxibustion therapy at Shenshu （BL 23） and Zusanli （ST 36） of rats with induced rheumatoid arthritis （RA） on the serumal intercellular cell adhesion molecule-1 （ICMA-1） and the pathological tissue, to discuss the mechanism of the warming and activating effect of moxibustion. Methods： After establishing the RA rats model, the induced rats were treated with moxibustion therapy on the acupoint Shenshu （BL 23） and Zusanli （ST 36）, followed by analyzing the pathological section of the ankle of the hind limb and testing the ICAM-1 content with ELISA. Results： The plantar circumferences of the induced rat increased significantly compared with the rats in the control group （P〈0.01）, accompanying with the increase of the synovial layer, the erosion of phlogocytes to chondrocytes and the specific increase of ICAM- 1 content. After the moxibustion therapy, the plantar circumferences decreased significantly （P〈0.01） while the synovial layer tended to reduce. In addition, there was no pathological damage of the articular cartilage and the ICAM content decreased with significant deviation （P〈0.01）, compared to the model group. Conclusion： It was concluded that moxibustion therapy could inhibit the arthrosynovitis and hyperplasia, ameliorate the erosion of phlogocyte to cartilage, prevent articular periosteal lesions and delay the pathological course. The warming and activating effect of moxibustion therapy may involve the inhibition of the formation of ICAM- 1 and pannus.
目的：观察艾灸肾俞、足三里穴对类风湿关节炎模型大鼠血清细胞粘附分子（intercellular cell adhesion molecule-1, ICAM-1 ）及病理组织的影响，探讨艾灸温通效应的作用机制。方法：建立类风湿关节炎大鼠模型。艾灸模型大鼠肾俞、足三里穴，分析比较大鼠的后肢踝关节病理切片的变化及运用酶联免疫吸附法（ELISA法）检测血清细胞粘附分子（ICAM-1）的含量。结果：模型大鼠与正常组比较，跖围明显肿胀（P〈0．01），滑膜层数增加，软骨受炎细胞侵蚀，血清ICAM-1的含量明显升高。艾灸治疗后跖围明显减小（P〈0．01），滑膜层数有减少的趋势，关节软骨未见病理性损伤，血清ICAM—1的含量下降，与模型组比较差异显著（P〈0．01）结论：艾灸具有抑制大鼠病变关节滑膜炎症与增生，改善炎性细胞对软骨的侵蚀，预防关节骨膜病变，延缓病理进程的作用；艾灸能抑制血清细胞粘附分子ICAM—1的产生，阻抑血管翳生成，可能是艾灸温经通络治疗实验性关节炎的作用机制之一。
