二次正交旋转组合设计法优化赤芍醇提工艺

Quadratic-Orthogonal-Rotation-Combination Design for Optimization of Ethanol Extraction Craft from Radix Paeoniae Rubra

目的:二次正交旋转组合设计法优化赤芍醇提工艺。方法:以芍药苷提取率为指标,乙醇浓度、提取时间、乙醇用量为考察因素,采用二次正交旋转组合设计法优选回流提取工艺条件,并进行预测分析。结果:最优提取工艺为:乙醇浓度73%,提取时间100 min,乙醇用量8.3倍。结论:中心组合设计法具有应用简便、预测性好等优点。

Objective： To optimize the ethanol extraction process of Radix Paeoniae Rubra（RPR） using quadratic-orthogonal-rotation-combination design.Methods： The influential factors were ethanol volume,ethanol concentration and extracting time.The evaluating indicator was the extraction rate of peoniflorin.The quadratic-orthogonal-rotation-combination design was used to optimize the process and the prediction was carried out.Results： The optimum conditions of extraction were 73% ethanol,100 min for extraction,volume of ethanol was 8.3 times.Conclusion： It shows that the optimum model is simple and highly predictive.