乌鲁木齐市公务员非酒精性脂肪性肝病患病状况分析

Prevalence of Nonalcoholic Fatty Liver Disease and Its Risk Factors in Civil Servant of Urumqi

目的 了解乌鲁木齐市公务员非酒精性脂肪性肝病（NAFLD）的患病率及相关危险因素,为早期发现和预防NAFLD提供基础资料.方法 选择乌鲁木齐市公务员健康体检者2 074人,分析其相关检查,包括一般资料、血生化检查资料及肝脏超声波检查结果.结果 乌鲁木齐市公务员NAFLD的患病率为34.09%,男性显著高于女性（P〈0.01）;在50岁组和60岁组维吾尔族NAFLD患病率高于汉族（P〈0.05）,50岁以前维吾尔族和汉族NAFLD患病率差异无统计学意义（P＞0.05）;NAFLD组TG,LDL-C,GLU,ALT,AST,γ-GT,BUN和CRE等均显著高于对照组（均P＜0.05）,HDL-C低于对照组（P＜0.05）;NAFLD组中肥胖、糖尿病、高血压、γ-GT升高等因素的发生率明显高于非脂肪肝组（P〈0.01）;Logistic回归分析显示饮酒、超重或肥胖、血脂异常、糖尿病、高血压病、年龄、低HDL-C、性别等因素与NAFLD关系密切（P〈0.01）.结论 乌鲁木齐市公务员NAFLD患病率高;血脂异常、肥胖及相关的多元代谢紊乱是NAFLD的可能危险因素;γ-GT测定可作为NAFLD的预测指标.

Objective To investigate the prevalence and,major risk factors of nonalcoholic fatty liver disease（NAFLD） among civil servant in Urumqi,and offer the basic information for early detection and prevention of NAFLD. Methods 2 074 civil servants in Urumqi were investigated. Questionnaire,physical examination,serum biochemical examination and ultrasonographic examination of liver were under taken. Results The prevalence of NAFLD in civil servants of Urumqi was 34.09% ,and it was markedly higher in males than that in females （P〈0. 01）. There was no significant difference on the prevalence of NAFLD between the Uygur and the Han in groups younger than 50 year old （P〉0. 05）,while in the 50- and 60- aging group ,the prevalence of NAFLD in the Uygur was higher than that in the Han respectively（P〈0.05）. The biochemical indexes include fasting serum glucose level （GLU）, triglyceride （TG）, low-density lipoprotein cholesterol （LDL-C）, γ-glutamyl transpeptidase （γ-GT）, atanine aminotransferase （ALT）, aspartate aminotransferase fAST）, Serum urea （BUN） and creatinine （CRE） in the NAFLD group was significantly higher than those in the group without fatty liver（P〈0. 05）,respectively,but the high-density lipoprotein cholesterol （HDL-C） level was lower in NAFLD group （P〈 0. 01 ）. The presence of obesity,diabetes mellitus, hypertension, dyslipidemia, heavy drinking and high γ-GT level in the NAFLD group was significantly higher than those in the group without fatty liver（P〈0. 01）,respectively. Logistic regression analysis demonstrated that the prevalence of NAFLD was positively correlated to seven factors,including male sex, obesity,drinking,diabetes mellitus,hypertension,dyslipidemia and lower HDL-C. Conclusion There is a high prevalence of NAFLD among civil servants in Urumqi. Metabolic disorders such as obesity and diabetes mellitus ,hypertension and hy- perlipidemia are probably the risk factors of NAFLD in Urumqi. The serum γ-GT level may be seen as a predict index of NAFLD.