高尿酸、高同型半胱氨酸血症与冠心病关系的探讨

Discussion the Relationship between Hyperuricemia, Hyperhomocysteinemia and Coronary Atherosclerotic Cardinopathy

目的 探讨高尿酸、高同型半胱氨酸血症与冠心病的关系.方法 检测经冠脉造影确诊的冠心病患者85例与80例健康体检者的血尿酸（UA）、血清同型半胱氨酸（Hcy）、胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平,依据冠脉造影分为单支冠脉狭窄（Ⅰ组）、双支冠脉狭窄（Ⅱ组）、三支冠脉狭窄（Ⅲ组）三组,并进行相关的统计学分析.结果 Ⅰ,Ⅱ,Ⅲ组间血尿酸和同型半胱氨酸水平比较差异有统计学显著性意义（P〈0.01）;其它生化指标TC,TG,HDL-C,LDL-C与对照组比较差异均有统计学显著性意义（P〈0.01）.Ⅰ组与Ⅱ组、Ⅱ组与Ⅲ组之间UA水平比较差异有统计学显著性意义（P〈0.05）,Ⅰ组与Ⅲ组UA水平比较差异有统计学显著性意义（P〈0.01）;Ⅰ组、Ⅱ组、Ⅲ组Hcy水平两两组之间比较差异有统计学显著性意义（P〈0.01）;三组间TC,TG,HDL-C,LDL-C比较差异无统计学意义（P〉0.05）.结论 高尿酸、高同型半胱氨酸血症是冠心病发病的重要危险因素之一.

Objective To explore the relationship between Hyperuricemia,Hyperhomocysteinemia and Coronary atheroscle- rotic Cardinopathy（coronary heart disease）. Methods 165 patients with suspected CHD were devided into two groups according to the results of coronary ateriography： CHD group and control group. The patients serum UA,Hcy, TC,TG, HDL-C and LDL-C were detected by the standard method. CHD group were devided into 1,2 and 3-vessel disease groups according to coronary ateriography,which was Ⅰ , Ⅱ and Ⅲ groups. Results QUA and Hcy level was elevated significantly in CHD group （P〈0.05）, and TC,TG, HDL-C and LDL-C had statistical difference between the two groups. （2） Group Ⅰ ,Ⅱ and Ⅲ ,UA and Hcy lever had statistical difference,UA lever had significent statistical difference in comparing group Ⅲ to Ⅰ （P〈0. 01）. Hcy lever had significent statistical difference among group Ⅱ ,Ⅲ and Ⅰ ,while others,TC, TG,HDL-C and LDL-C,had no statistical difference. Conclusion Hyperuricemia,Hyperhomocysteinemia were independent risk factori in CHD.