西安地区儿童手足口病病原学分析

Study on Etiology of Hand,Foot and Mouth Disease （HFMD） in Xi＇ an

目的 对西安地区手足口病病原学进行分析调查,为手足口病防治提供科学依据.方法 采集2010年5月～6月432例临床诊断为手足口病患儿咽拭子标本,采用实时荧光RT-PCR方法检测肠道病毒通用型（EV）、肠道病毒71型（EV71）和柯萨奇病毒A16型（CA16）.结果 EV阳性率82.87%（358/432）,EV71阳性率25.93%（112/432）,CA16阳性率21.06% （91/432）,EV71阳性率与CA16阳性率比较差异无统计学显著性意义（χ2=2.84,P〉0.05）.22例重症患者11例由EV71引起,2例由CA16引起.结论 西安地区手足口病病原以EV71和CA16多见,高发于4岁以下儿童,重症患者主要由EV71引起.

Objective Study was aimed to analyse the etiology of Hand-Foot-Mouth disease （HFMD） in Xi＇an,in order to provide a basis for the prevention and treatment of HFMD. Methods Throat swabs of 432 children, clinically diagnosed as HFMD during May to June in 2010 were collected. Real-time RT-PCR was used to detect Enterovirus （EV） ,Enterovirus 71 （EV71） and Coxsackievirus A16 （CA16）. Results The positive rate of EV,EV71 and CA16 were 82.87% （358/432）, 25.93% （112/432） and 21.06% （91/432） respectively. The positive rate of EV71 was not significantly different from that of CA16 （χ2=2.84,P〉0.05）,I1 of 22 severe HFMD cases were caused by EV71,while 2 of 22 were caused by CA16. Conclusion HFMD were commonly caused by EV71 or CA16 and popular in children under age 4. Severe cases of HFMD were mainly caused by EV71.