控制性超促排卵在FSH/LH搭配中添加hCG又如何?

What about adding hCG to FSH/LH in controlled ovarian hyperstimulation?

近三十年，随着辅助生殖技术的进展，控制性超促排卵（controlled ovarian hyperstimulation，COH）的作用愈来愈重要。同时，促排卵用药方案也不断改进与优化。人黄体生成素（LH）在COH中的作用由初始的“恐惧和忽略”逐渐获得重新认识与重视。LH、人绒毛膜促性腺激素（hCG）及卵泡刺激素（FSH）属同一类糖蛋白家族，

Human chorionic gonadotropin （hCG） and luteinizing hormone （LH） are two members of the glycoprotein hormone family and both of them share a common receptor-LH/hCG receptor. The expression of the LH/hCG receptors is regulated by many factors including estrogen and follicle-stimulating hormone （FSH）. LH plays an important role in ＂two cells two gonadotropins＂ theory. LH induces local production of soluble molecules such as IGF throughout folliculogenesis, hCG has similar activity to LH. Some researchers added hCG with FSH in the mid-late follicular phase in controlled ovaries hyperstimulation （COH）. The pregnancy rate was not significantly different in hCG addition group, but the gonadotropin dose was reduced significantly, which can be a good saving for the patients. Some scholars even thought that hCG can replace FSH in the late follicular phase in COH.