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瑞格列奈联合甘精胰岛素治疗老年2型糖尿病及其安全性分析 被引量:24

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摘要 目的评价瑞格列奈联合甘精胰岛素在老年2型糖尿病治疗中的疗效和用药安全性。方法选择90例老年2型糖尿病患者作为研究对象,按照随机原则分成瑞格列奈+甘精胰岛素组(治疗组,45例)和口服药+预混胰岛素组(对照组45例)。甘精胰岛素加瑞格列奈组采用三餐前口服瑞格列奈,睡前皮下注射甘精胰岛素;预混胰岛素加口服药组采用早、晚餐前30min皮下注射预混胰岛素,中餐前口服瑞格列奈或阿卡波糖。两组患者治疗时间至少16周,期间均根据血糖水平调整用药量,观察两组空腹血糖、餐后2h血糖、糖化血红蛋白水平、空腹C肽、餐后2hC肽及低血糖发生情况。结果治疗后两组患者空腹血糖、餐后血糖、糖化血红蛋白均较治疗前明显下降(P<0.05);治疗组空腹C肽、餐后2hC肽治疗后明显上升(P<0.05),对照组治疗前后差异则无统计学意义(P>0.05)。治疗组低血糖发生率低于对照组(P<0.05)。结论瑞格列奈联合甘精胰岛素治疗老年2型糖尿病疗效明显,不良反应发生少,易被患者接受。
作者 王秀荣
机构地区 迁西县人民医院
出处 《南方医科大学学报》 CAS CSCD 北大核心 2010年第7期1707-1708,共2页 Journal of Southern Medical University
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