先天性心脏病患者皮纹波动不对称性的研究

Fluctuating Asymmetry of Dermatoglyphics in Individuals with Congenital Heart Disease

本文采用随机整体抽样的方法分析了先天性心脏病患者129例(男性59例,女性70例)和正常对照人群133例(男性69例,女性64例)13项皮纹波动不对称性(Fluctuating asymmetry,FA)的分布特征。结果表明:(1)先天性心脏病患者组与正常对照组在13项皮纹波动不对称性指标中均未出现显著性别差异;(2)先天性心脏病患者组与正常对照组在FAⅥ(P<0.05)和FAⅦ(P<0.01)两项有显著性差异,表现为患者组明显增高,提示先天性心脏病患者在胚胎发育早期易受到环境因素影响,具有较高的发育不稳定性。

The purpose of this paper is to analyze the fluctuating asymmetry （FA） of the dermatoglyphic count in individuals with congenital heart disease （CHD） from Ningxia, China. Fluctuating asymmetry refers to small random deviations from perfect symmetry in bilaterally paired structure, and is the result of interactions between developmental disturbance and developmental stability. Fluctuating asymmetry has a low heritability, and can be a measure of individual quality but also an indicator of developmental stability. Computing FA was done using the absolute differences between bilateral measurements （ calculated as FA = ｜ R - L ｜ ） , and in order to avoid count and measure error, we choose the equation, FAij = 100 ×｜ （XiR -XiL） /0. 5 ＊ （XiR ＋ XiL） - 1/n × [ （XiR - XiL） /0.5 × （XiR ＋ XiL） ] ｜. A random sample of 129 CHDs （59 males and 70 females） was compared to 133 healthy controls （69 male and 64 female） , with a study of 13 FA counts between them. The results were as follows： 1. There was no significant difference between two sexes in both CHDs and controls in all 13 FA counts; 2. There was a significant difference in FA VI and FA VII between two groups, and that CHD patients had significantly higher FA rates. These results may indicate that during the course of fetal development, the CHD fetus is much more senstive to a variety of external environmental factors and thus, has higher developmental instability.