5-硝基吲唑-3-甲酰甘氨酸钠对小鼠肝癌的放射增敏效应

Radiosensitization of Murine Hepatoma by 5-Nitroindazole-3-formyl Glycine

目的采用动物肿瘤模型探讨5-硝基吲唑-3-甲酰甘氨酸钠的放射增敏效应。方法将移植有肝癌的昆明种小鼠随机分为4个组:乏氧对照组(阻断小鼠荷瘤肢体血流10min)、乏氧用药组(分为高、中、低3个亚剂量组腹腔内单次注射给药)、乏氧放射组(6Gy单次照射)、乏氧放射+药物组(给药后1小时乏氧条件下单次照射),每组8只小鼠。采用肿瘤生长延缓方法进行放射增敏实验。结果当肿瘤体积达到实验开始体积3倍时,分别测得乏氧放射+药物的高、中、低剂量组的放射增敏比分别为1.75、2.0、1.25,平均为1.67。结论 5-硝基吲唑-3-甲酰甘氨酸钠对小鼠肝癌具有放射增敏效应,且在实验剂量范围内对小鼠无毒性。

Objective To investigate the radiosensitizing effect of 5-Nitroindazole-3-formyl Glycine on animal model.Methods Kunming mice transplanted with H22 hepatoma were divided into 4 groups randomly,5-Nitroindazole-3-formyl Glycine alone（divided into 3 sub-group）,radiation alone,radiation combinated with 5-Nitroindazole-3-formyl Glycine（divided into 3 sub-group）,each group including 8 mice.The blood flow in the tumor bearing leg of every mouse was interrupted for 10 min for hypoxia.Method of tumor growth delay was used in the experiment.Results Sensitizing enhancer ratio on the 3 groups was 1.75、2.0、1.25 respectively.Conclusion 3 dosages of 5-Nitroindazole-3-formyl Glycine all have radiation-sensitizing effection on H22 hepatoma and are avirulent to mice.