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病理性瘢痕细胞通讯相关靶点药物研究现状 被引量：2

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摘要 病理性瘢痕包括增生性瘢痕和瘢痕疙瘩，以过度的Fb增殖和ECM沉积为主要特征。研究表明，表皮细胞、Fb、血管内皮细胞以及炎性细胞等的功能、增殖或凋亡异常，促纤维化与抗纤维化信号的表达失控，ECM的沉积与降解失衡等，均与细胞通讯异常有关。因此，改善这种失衡状态成为研发抗瘢痕药物的新方向。
作者 吴志宏张立超陈海滨 吴志宏 张立超 陈海滨
机构地区 上海市第七人民医院烧伤整形科 上海市第七人民医院药剂科 宁夏医科大学研究生院
出处 《中华烧伤杂志》 CAS CSCD 北大核心 2010年第4期322-324,共3页 Chinese Journal of Burns
基金 基金项目：上海市重点专科建设项目（0511014） 上海市浦东新区项目（PKJ2008Y23、PWRd2008-07）
关键词 病理性瘢痕 抗瘢痕药物 细胞通讯 靶点 Fb增殖 血管内皮细胞 抗纤维化 增生性瘢痕
分类号 R619.6 [医药卫生—外科学]
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参考文献14

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共引文献5

同被引文献40

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二级引证文献7

中华烧伤杂志
2010年 第4期

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