中国汉族女性中G72基因与精神分裂症的关系

Association of G72 gene locus with schizophrenia in Chinese females of Han ethnicity

目的研究在中国汉族女性中NMDA受体途径重要基因G72与精神分裂症的关系。方法在545名中国汉族女性(精神分裂症患者260例,正常对照285例)中对位于G72基因的3个单核苷酸多态性位点(rs3916965、rs3916967和rs2391191)进行基因分型和连锁不平衡分析。结果遗传标记rs3916967的等位基因G(P=0.0386)和rs2391191的等位基因A(P=0.0096)均与精神分裂症相关。此外,由3个单核苷酸多态性位点构建的单倍型分析表明,单倍型GAG在病例-对照组中表现出统计学差异(P=0.0024)。结论在中国汉族女性中,G72基因是精神分裂症的一个重要易感基因,在后续的研究中有必要对本结果进行进一步的验证。

Objective To examine the relationship between G72 gene locus（an important gene of NMDA receptor pathway） and schizophrenia in Chinese females.Methods We genotyped three single-nucleotide polymorphisms（rs3916965,rs3916967 and rs2391191） in G72 gene locus region in 545 Chinese females of Han ethnicity（260 schizophrenia cases and 285 healthy controls） and performed the linkage disequilibrium analysis.Results Significant association was found between two SNPs and schizophrenia（P = 0.038,6 for the allele G of rs3916967 and P = 0.009,6 for the allele A of rs2391191）.Furthermore,three SNPs were used in multiple haplotype analysis and significant difference was found for the common haplotype GAG（P = 0.002,4）.Conclusion G72 gene may be a candidate susceptible gene for schizophrenia in the Chinese females of Han ethnicity.Further efforts are warranted to confirm our findings.