冠心病患者血浆salusin-α水平及其临床意义

Plasma level of salusin-α in patients with coronary heart disease and its clinical implications

目的探讨salusin-α水平与冠心病冠脉病变稳定性、严重程度及冠心病危险因素的关系。方法选择住院的122例经冠状动脉造影确诊的冠心病患者作为病例组,病例组再分别根据临床类型、冠脉病变支数、Gensini积分分为若干个亚组;门诊健康受试者60例作为对照组。所有受试者均测定外周血salusin-α水平及一般生化指标,收集一般临床资料。结果冠心病患者外周血salusin-α水平明显低于正常对照组[(0.50±0.18)ng/mlvs(0.69±0.23)ng/ml,P<0.01]。急性冠脉综合征患者salusin-α水平明显低于稳定性心绞痛患者[(0.46±0.17)ng/mlvs(0.56±0.19)ng/ml,P<0.01];Salusin-α水平在Gensini积分0～20组、20～40组和≥40组3组间无统计学差异,在单支病变组、双支病变组、三支病变组间亦无统计学差异。结论冠心病患者salusin-α水平可能与冠脉病变的稳定性相关,但不能反映冠脉粥样硬化病变的严重程度。

Objective To explore the relationship of plasma salusin-α level with the stability,severity,and other risks of coronary atherosclerosis.Methods The patient group included 122 hospitalized patients with coronary artery disease（CAD）,whose diagnoses were confirmed by coronary angiography（CAG）.The CAD group was further divided into subgroups according to the clinical types,the number of diseased coronary branches,and Gensini＇s scores.Control group inlcuded 60 healthy subjects who underwent physical examination in our hospital.Salusin-α level and other general biochemical indicators were determined,and the general clinical data were obtained before CAG in all subjects.Results The peripheral blood salusin-α level in CAD patients was significantly lower than that in the controls（[0.50±0.18]ng/ml vs [0.69±0.23 ng/ml],P0.01）,and that in the acute coronary syndrome patients was significantly lower than that in the stable angina pectoris patients（[0.46±0.17]ng/ml vs [0.56±0.19]ng/ ml,P0.01）.Salusin-α levels were not significantly different between patients with different Gensini＇s scores or between patients with 1,2 and 3 diseased branches.Conclusion Peripheral blood salusin-α level might be associated with stability of the CAD,but not with the severity of coronary atherosclerosis.