细胞膜磷脂酰肌醇4,5-二磷酸对TRP通道功能的调节作用

Regulatory role of phosphatidylinositol 4,5-bisphosphate in transient receptor potential channel

TRP离子通道超家族可分为7个亚族,其功能受多方面因素的调节。最近的研究证明磷脂酰肌醇-4,5-二磷酸(PIP2)对多个家族的TRP通道功能均有调节作用,而且调节的结果既可以是激活也可以是抑制,作用比较复杂,涉及的机制和因素较多。本文综述了PIP2对几种不同家族TRP通道的调节作用及其病理生理学意义。

Transient receptor potential（TRP） superfamily includes seven subfamilies and TRP channels are regulated by a wide variety of physical and chemical factors.Recently,several members of the TRP channel family have been reported to be regulated by phosphatidylinositol 4,5-bisphosphate（PIP2）.The regulation is complex and it can be activation or inhibition,involving multiple mechanisms and factors.This review summarizes the PIP2 regulation of several TRP channels of different superfamilies and the related pathophysiological significance.