他克莫司软膏联合口服中药治疗面部激素依赖性皮炎临床观察

Cinical observation of topical Tacrolimus ointment therapy combination with oral Chinese medicine treatment in facial corticosteroid-dependent dermatitis

目的:评价单纯外用他克莫司软膏和外用他克莫司软膏联合口服中药治疗面部激素依赖性皮炎的临床疗效。方法:将60例患者随机分成单纯外用他克莫司软膏治疗组和外用他克莫司软膏联合口服中药治疗组,两组患者分别于治疗后进行临床疗效评估及治疗结束后进行4周随访观察。结果:4周治疗结束时,单纯西药治疗组的有效率为73.2%,中西药联合治疗组的有效率为93.3%,两组疗效差异有显著性(P<0.05)。结论:外用他克莫司软膏联合口服中药治疗面部激素依赖性皮炎优于单纯外用他克莫司软膏治疗。

Objective To observe the clinical effectiveness of topical Tacrolimus ointment therapy combination with or without oral Chinese medicine treatment in facial corticosteroid-dependent dermatitis.Methods Sixty patients with facial corticosteroid-dependent dermatitis were randomly divided into topical Tacrolimus ointment therapy group and topical Tacrolimus ointment therapy combination with oral Chinese medicine treatment group.The patients in these two groups received continuous treatment for 4 weeks and follow-up for additional 4 weeks.Results Total effective rate was 73.2% in topical Tacrolimus ointment therapy group,and was 93.3% in topical Tacrolimus ointment therapy combination with oral Chinese medicine treatment group.There was a significant difference between the two groups in the total effective rates（P〈0.05）.Conclusions The curative effect of the topical Tacrolimus ointment combined with oral Chinese medicine group is better than the topical Tacrolimus ointment group.