蛋白芯片法检测肺感染患者多肿瘤标志物的变化

Analysis of multiple tumor markers in patient with pulmonary infection

目的:探讨肺感染患者多肿瘤标志物的变化及临床意义。方法:采用C12检测20例老年肺感染合并胸水患者、25肺感染无胸水患者、30例无肺部病变健康人12种肿瘤标志物水平。结果:肺感染无胸水组、肺感染合并胸水组血清ferritin浓度均显著高于对照组(P均<0.01),而这两组间差异无统计学意义。合并胸水组的血清CA125、CA15-3浓度均显著高于对照组和肺感染无胸水组(P<0.05,P<0.01),而对照和肺感染无胸水组间这两个指标比较无显著差异。其它指标各组间比较均无显著差异。肺感染合并胸水组,胸水中ferritin、CA125的浓度分别为281.3±103.2和389.1±71.1,均显著高于对应病例血清水平(P均<0.01)。血清与胸水间只有ferritin有相关性r=0.537,P<0.05。结论:肺感染患者血清某些肿瘤标志物异常,其血清浓度升高与胸水生成有关。

Objective：To explore the change and clinic significance of multiple tumor markers in patient with pulmonary infection.Methods： Patients with only pulmonary infection group（25）,pulmonary infection combined pleural fluid group（20）,and control group（30） were enrolled.Twelve tumor markers in serum and pleural fluid（AFP,CEA,NSE,CAl25,CAl53,CA242,CAl99,PSA,f-PSA,FER,β-HCG and HGH） were measured by the multi-tumor markers protein biochip detective system.Results： The serum concentration of ferritin in the two pulmonary infection group was significantly higher than that in control group.However,no significant difference in fettitin was found between the two pulmonary infection group（P〈 all0.01）.The serum levels of CA125 and CA15-3 in patients with pleural fluid were significantly higher than that in patients with only pulmonary infection and controls（P〈0.05,P〈0.01）.In patients with pleural fluid,the levels of ferritin and CA125 in pleural fluid were significantly higher than in serum（P all〈0.01）.Moreover,the level of ferritin in pleural fluid was significantly correlated with that in serum（r=0.537,P〈0.05）.Conclusion： Serum levels of several tumor markers of patients with pulmonary infection are abnormal.The higher serum level of tumor markers is associated with production of pleural fluid.