2009年平顶山市儿童手足口病病原分析

Pathogen of hand,foot and mouth disease in children in pingdingshan in 2009

目的:通过了解2009年平顶山市手足口病的病原学特征,为手足口病防治工作提供科学依据。方法:收集2009年3～12月468例手足口病患儿的粪便、血清、咽拭子、疱疹液、脑脊液标本共764份,用RT-PCR进行检测。结果:468例被检测患儿中318例为肠道病毒阳性,阳性率为67.95%,其中EV71感染最高,占37.18%。764份标本中有452份检测出肠道病毒阳性,总阳性率为59.16%,其中粪便标本阳性检出率最高,为67.65%。重症患儿肠道病毒阳性检出率为76.39%,EV71阳性116例,占70.30%。男性发病多于女性,男女比为1.75∶1,男性肠道病毒阳性检出率高于女性(χ2=7.7454,P=0.0054)。肠道病毒阳性病例主要集中4岁以下儿童,占93.36%。结论:平顶山市2009年儿童手足口病病原体以EV71为主,粪便标本中PCR阳性率检出较高。

Objective：Scientific proof of HFMD prevention and cure is provided by knowing the etiologic features of HFMD in Pingdingshan in 2009.Methods： Tests are done with RT-PCR by collecting 764 specimens from 468 HFMD children＇s feces serum,nasopharyngeal swab,fluid from blisters,and CSF.Results： 318 children are tested positive for enterovirus from 468 with rate is 67.95%,among of that EV71 infections rate is the highest which is 37.18%.452 out of 764 specimens are tested positive for enterovirus with rate of 59.16%,in which stool specimen tested positive is 67.65%.Severe children tested positive for enterovirus is 76.39% and of which 116 are tested EV71 infection which accounts for 70.30%.The HFMD happens more in male than that in female by ratio of 1.75∶1.Male tested positive for enterovirus is higher than that in female.93.36% tested positive for enterovirus are children below age 4.Conclusion： EV71 pathogen serves to be the main source in children HFMD and feces specimens test PCR positive appears high in children in Pingdingshan in 2009.