海南地区类鼻疽假单胞菌感染的临床研究

Clinical investigation of Burkholderia pseudomallei infection in the area of Hainan

目的探讨类鼻疽病的临床特征及诊治经过,以提高对该病的诊断治疗水平。方法分析1996～2009年在海南省人民医院治疗的63例类鼻疽假单胞菌感染者的临床特征、诊断方法及治疗过程。结果类鼻疽假单胞菌易感染糖尿病等基础病患者,临床表现多样,误诊率高,可选用敏感药物少。亚胺培南或美洛培南对多数患者具有较好的效果,而部分患者可采用头孢他啶、复方新诺明及氯霉素等抗生素联合用药,均能取得较好的疗效。结论早期采集标本进行细菌培养和药敏检查,以便提高类鼻疽假单胞菌感染病的诊断率,并且尽早使用敏感药物,使患者能够得到有效的治疗。

【Objective】To analyze the clinical characteristics of patients infected with Burkholderia pseudomallei so as to enhance the levels in diagnosis and treatment of the infections.【Methods】The clinical symptom and methods in diagnosis and treatment methods of 63 cases with Burkholderia pseudomallei from 1996 to 2009 in the Hainan Provincial People’s Hospital were analyzed.【Results】The symptoms of this disease were not specific and the misdiagnositc rate was high.The patients infected with Burkholderia pseudomallei were prone to be infected with diabetes.Only few effective and sensitive drugs were chosen.Usually,meropenem or imipenem was effective,but lots of patients could be chosen some drugs,for example,ceftazidime,compound-sulfamethoxade and chlormycetin,etc.【Conclusion】The priority measures are to enhance laboratory diagnosis rate of Burkholderia pseudomallei and chosen effective drugs for treatment of the infection as early as possible.