早期强化空腹血糖治疗对初发2型糖尿病β细胞功能的影响

Fasting Blood Glucose Early Intensive Treatment in Type 2 Diabetes β Cell Function

目的:探讨早期强化空腹血糖治疗对初发2型糖尿病(T2DM)β细胞功能的影响。方法:将我院2008-01～2010-01收治的T2DM患者54例按空腹血糖浓度分为1组28例(FPG<10.0mmol/L)、2组12例(10.0mmol/L≤FPG<13.0mmol/L),3组14例(FPG≥13.0mmol/L)。结果:FINS、2h-INS均为1组>2组>3组。其中FINS除1组与2组差异有显著性外(P<0.01),其余各组差异无显著性(P>0.05)。2h-INS3组组差异显著(P<0.01)。HBCI在T2DM3组间差异有显著性(P<0.01)。结论:空腹血糖浓度低患者的胰岛素分泌和释放处于相对较高水平。不同空腹血糖浓度的T2DM患者胰岛β细胞功能随空腹血糖升高而显著下降。

Objective：To investigate the early intensive blood glucose treatment in Type 2 diabetes mellitus（T2DM） β cell function.Methods：To our hospital from January 2008 to January 2010 were treated 54 cases with type 2 diabetes by fasting glucose divided into a group of 28 cases（FPG 10.0 mmol/L）,2 groups 12 cases（10.0 mmol/L ≤ FPG 13.0 mmol/L）,3 groups14 cases（FPG ≥13.0 mmol/L）.Results：FINS,2h-INS are a group group2 group 3.FINS addition to a group in which 2 groups were significantly different outside（P 0.01）,the other groups no significant difference（P 0.05）.2h-INS three groups significantly different（P 0.01）.HBCI in T2DM differences among the three groups was significant（P 0.01）.Conclusions：Fasting blood glucose levels in patients with low insulin secretion and release at a relatively high level.Fasting blood glucose concentrations in different β-cell function in patients with T2DM with elevated fasting blood glucose decreased significantly.