脑信号导向蛋白Semaphorins3F与难治性癫痫

Brain Signal Guidance Protein,Semaphorins3F And Intractable Epilepsy

在神经发育过程中Semaphorins为轴突导向和神经细胞的迁移提供导向信息。这些导向分子通过抑制自发的或异常的轴突生长来维持己建立的神经连接,并参与突触可塑性以及中枢神经受损后抑制神经再生与神经细胞的死亡。目前,虽然对Semaphorins在神经发育、成熟及受损不同阶段中的功能己有初步的了解,但Semaphorins其受体多样,尚无法预测Sema-phorins与其受体的结合将产生的生物学效应以及Semaphorins在神经系统中起作用的分子机制。进一步研究Semaphorins对癫痫、精神分裂、老年痴呆症等神经系统性疾病的治疗具有深远意义。

In neural development, Semaphorins offer the information to the axon guidance and neuroeyte migration. These guidance molecules keep the nerve conjunction by inhibiting the axon growth. They also take part in the axon plasticity, inhibiting nerve regeneration after central nerve damage and nerve cell death. At present, there are some study about the role of Semaphorins in nerve development, maturation and different stage in damage. But receptors of Semaphorins are multiple, biological effect and the molecule mechanism in neural system have not be clarified. Great significance of investigating Semaphorins is showed in neural system disease, like epilepsy, schizophrenia and senile dementia.