Maspin、血管内皮生长因子在子宫内膜样腺癌中的表达及意义

Expression and significance of Maspin, vascular endothelial growth factor in endometrioid adenocarcinoma

目的 观察子宫内膜样腺癌组织中Maspin、血管内皮生长因子（VEGF）的表达.方法 采用免疫组织化学SP法检测49例子宫内膜样腺癌、12例子宫内膜不典型增生及15例正常子宫内膜组织中的Maspin和VEGF表达情况.结果 Maspin在正常子宫内膜组织中未见表达,在子宫内膜不典型增生组织（41.7%,5/12）和子宫内膜样腺癌组织（59.2%,29/49）中阳性表达率逐渐增高（P＜0.01）,VEGF在正常子宫内膜组织（13.3%,2/15）、子宫内膜不典型增生组织（33.3%,4/12）和子宫内膜样腺癌组织（67.3%,33/49）中阳性表达率逐渐增高（P＜0.01）;Maspin表达与子宫内膜样腺癌的FIGO分期有关（P=0.034）,VEGF表达与子宫内膜样腺癌的肌层浸润深度有关（P=0.036）;Maspin与VEGF的表达呈正相关（r=0.307,P＜0.05）.结论 Maspin、VEGF与子宫内膜样腺癌的发展、侵袭相关,二者的异常表达共同作用促进子宫内膜样腺癌的发展和侵袭.

Objective To analyze the expression and clinical significance of Maspin, vascular endothelial growth factor （VEGF） in endometrioid adenocarcinoma tissue samples. Methods Forty-nine cases of endometrioid adenocarcinoma, 12 cases of atypical hyperplasia of endometrium and 15 cases of normal endometrium were selected. Immunohistochemistry was used to study the expression of Maspin,as well as VEGF. Results The expression of Maspin was none in normal endometrium,while the positive rates of Maspin in atypical hyperplasia of endometrium （41.7%, 5/12 ） and endometrioid adenocarcinoma （59.2%,29/49） were ascending, there was statistical significance among the three groups （P〈0.01 ）. The positive rates of VEGF in normal endometrium （ 13.3%, 2/15 ）, atypical hyperplasia of endometrium （ 33.3%, 4/12 ）,endometrioid adenocarcinoma （67.3% ,33/49） also were ascending （P〈 0.01 ）. The expression of Maspin was related with the FIGO stage in endometrioid adenocarcinoma （P=0.034）, and the expression of VEGF was related with the myometrial invasion（P = 0.036）. There was positve correlation between the expression of Maspin and VEGF （r = 0.307,P〈0.05）. Conclusions The expression of Maspin, VEGF in tumor tissue has a significant correlation with the level of invasion of endometrioid adenocarcinoma. The expressions of Maspin,VEGF apparently play an essential role in the development and invasion of endometrioid adenocarcinoma.