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不同术式治疗宫颈上皮内瘤变Ⅲ效果比较及随访策略分析 被引量：2

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摘要 目的 探讨不同术式治疗宫颈上皮内瘤变（CIN）Ⅲ的效果,结合术后液基薄层细胞学检查（TCT）及高危型（HR）-人乳头瘤病毒（HPV）DNA检测预测CINⅢ复发,为手术方式个体化选择提供参考,并探索更为经济有效的随访方案.方法 回顾性分析158例CINⅢ患者分别采用子宫全切术、宫颈冷刀锥切术（CKC）、宫颈环形电锥切术（LEEP）治疗后病变残留及复发情况,评价三种术式的有效性.对术后TCT、HR-HPV DNA检测阳性结果与活检或二次手术病理结果比较,分析TCT、HR-HPV DNA检测预测CINⅢ术后复发的效能.结果 子宫全切术患者复发率为5.26%（4/76）,CKC患者为6.25%（2/32）,LEEP患者为8.00%（4/50）,三者复发率两两比较差异均无统计学意义（P＞0.05）;CINⅢ术后HR-HPV DNA检测的阴性预测值为100.00%（134/134）;术后1～3个月HR-HPV DNA检测结果转阴率最低（52.17%,12/23）,与术后4～6个月（80.00%,36/45）、7～9个月（85.57%,83/97）、10～12个月（85.71%,48/56）转阴率比较差异均有统计学意义（P＜0.05）.结论 CINⅢ患者行子宫全切术不能降低术后复发率;CINⅢ患者术后3个月开始行TCT与HR-HPVDNA联合检测筛查,是性价比较高的随访策略.
作者 陈志敏 史惠蓉 王杨
机构地区 郑州大学第一附属医院妇产科
出处 《中国医师进修杂志》 2010年第24期53-55,共3页 Chinese Journal of Postgraduates of Medicine
关键词 宫颈上皮内瘤样病变 子宫切除术 宫颈冷刀锥切术 宫颈电环锥切术
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献11

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共引文献115

同被引文献17

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中国医师进修杂志
2010年 第24期

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