大承气汤联合抗生素对急性胰腺炎患者凝血功能的影响

Influence of Major Purgative Decoction combined with antibiotics on the coagulation function of patients with acute pancreatitis

目的探讨“大承气汤”联合抗生素对急性胰腺炎患者凝血功能的影响。方法急性胰腺炎患者100例，均分成治疗组及对照组，治疗5～10d。治疗前、后3d和7d抽外周静脉血检测血小板计数（PLT），凝血酶原时间（PT），活化部分凝血活酶时间（APTT），纤维蛋白原（FIB）。结果治疗后7d，治疗组PT，APTT显著短于对照组；PLT计数显著高于对照组；APTT，FIB显著低于对照组（均P〈0．05）。结论“大承气汤”对急性胰腺炎患者凝血功能有一定的影响。

Objective To investigate the influence of Major Purgative Decoction combined with antibiotics on the coagulation function of the patients with acute pancreatitis. Methods One hundred patients with acute pancreatitis, 68 males and 32 females, aged 44.6 （20-70）, were randomly divided into 2 equal groups： control group undergoing conventional comprehensive treatment including antibiotics, and Major Purgative Decoction group taking orally Major Purgative Decoction once a day for 5-5 days in addition to the above mentioned conventional treatment. Before the treatment and 3 and 7 days after treatment peripheral blood samples were collected to examine the blood platelet （PLT）, prothrombin time （PT）, activated partial thromboplastin time （APTT）, and fibrinogen （FIB）. Results Seven days after the treatment, the PT and APTT levels of the Major Purgative Decoction group were both significantly shorter than those of the control group, the FIB of the Major Purgative Decoction group was significantly lower than that of the control group, and the PLT count of the Major Purgative Decoction group was significantly higher than that of the contgrol gtoup （all P〈0.05）. Conclusion Major Purgative Decoction effectively ameliates the coagulation in the patients with acute pancreatitis.