产白介素-17T细胞在肺部细菌感染中的研究进展

Reseach progress on IL-17-producing T cells and pulmonary bacterial infection

目前产白介素-17(IL-17)T细胞主要包括了产IL-17 CD4+T细胞即Th17细胞、产IL-17γδT细胞和产IL-17 CD8+T细胞等。随着对Th17这一系细胞功能研究的不断深入,发现它们能通过产生IL-17和IL-22等细胞因子参与炎症反应。该文将对产IL-17 T细胞在肺部细菌感染中所起作用的最近研究进展进行综述。

Interleukin-17 is a proinflammatory cytokine that is produced by a variety of cells,including a newly identified subset of activated CD4＋ T cells（Th17 cells）,γδ T cells,CD8＋ cells and NKT cells.Th17 cells are thought to be a distinct lineage of Th cells that mainly produce IL-17,IL-22 and other cytokines which are involved in inflammatory response.γδ T cells have also been shown to be a potent source of IL-17 and,in some cases,produce more IL-17 than αβ T cells.IL-17-producing T cells are important in the host defense against acute pulmonary infection during the early immune response,also have the potential to elicit detrimental responses during chronic infection-related inflammatory conditions.This review will introduce recent research progress on the role of IL-17-producing T cells in the pulmonary bacterial infection.