维拉帕米对左室舒张期心力衰竭患者的疗效观察

Therapeutic effect of verapamil for patients with left ventricular diastolic heart failure

目的:探讨维拉帕米对左室舒张期心力衰竭患者的疗效。方法:84例舒张期心力衰竭患者,随机分成A组,42例,给予血管紧张素转换酶抑制剂(ACEI)+利尿剂标准治疗;B组,42例,在标准治疗基础上加用维拉帕米,随访30周。治疗前后测量六分钟步行试验的距离和检测血浆脑钠肽(BNP)的浓度进行对比,评价维拉帕米对单纯左室舒张期心力衰竭(DHF)的疗效。结果:维拉帕米治疗30周后与A组相比,B组6min步行距离明显提高(P<0.05);血浆BNP浓度明显降低(P<0.05)。结论:维拉帕米联用ACEI+利尿剂能进一步改善DHF患者的左室舒张功能,疗效确切。

OBJECTIVE To investigate the therapeutic effect of verapamil for patients with left ventricular diastolic heart failure （DHF）, METHODS Eighty four patients with DHF were randomly divided into group A （n = 42） who were given standard treatment including ACEI and diuretic and group B （n = 42） who were administrated verapamil and standard treatment,for 30 weeks. Before and after treatment the 6-minute walk test and plasma brain natriuretic peptide （BNP） concentra- tions were measured in order to evaluate the effect of verapamil on left ventricular diastolic heart failure. RESULTS Compared with group A, distance of 6 minute walk remarkably improved （P〈0. 05）and BNP concentration in plasma significantly decreased in group B （P〈0, 05） after 30 weeks. CONCLUSION Verapamil combined with ACEI and diuretic can definitely improve the left ventricular diastolic function of DHF.