乳腺癌术后3种化疗方案的药物经济学评价

Cost-effectiveness analysis of three chemotherapy schemes in postoperative treatment of soaked mammary cancer

目的:评价CEF、CMF及卡培他滨用于乳腺癌术后预防乳腺癌复发的经济学效果。方法:82例乳腺癌术后患者分为3组,分别给予CEF、CMF及卡培他滨(CA)的方案进行治疗,观察3组的疗效及不良反应,并进行成本-效果分析。结果:3组方案总有效率分别为75.00%,67.85%,72.72%,总成本分别为27121.76元,16150.30元和30701.20元;成本-效果比分别为361.62,238.02,422.18,CEF组各种不良反应发生率明显高于CMF组及卡培他滨组,差异有显著性(P≤0.05),而CMF组成本-效果比最小。结论:CMF治疗乳腺癌术后预防乳腺癌复发为较佳方案。

OBJECTIVE To evaluate the cost-effectiveness of three chemotherapy schemes in postoperative treatment of mammary cancer. METHODS 82 postoperative patients with mammary cancer were divided into three groups, and respectively treated with 3 schemes of CEF,CMF,and CA. The curative effects were analyzed by cost-effectiveness method. RESULTS The costs for the groups of CEF,CMF and CA, respectively 27 121.76 yuan, 16 150. 30 yuan and 30 701.20 yuan, and the effective rates for the three groups were respectively 75. 00%, 67. 85 %, and 72. 72 %. The three groups cost-effectiveness ratios were 361.62,238.02 and 422. 18. CONCLUSION Scheme CMF is a better approach.