5-氨基水杨酸与柳氮磺胺吡啶治疗溃疡性结肠炎的对比研究

COMPARISON OF THE EFFICACY OF 5 ASA AND SASP IN TREATMENT OF ULCERATIVE COLITIS

目的：比较５氨基水杨酸（５ＡＳＡ）和柳氮磺胺吡啶（ＳＡＳＰ）治疗轻、中型溃疡性结肠炎的临床疗效与不良反应。方法：于２年内连续收集经结肠镜确诊的溃疡性结肠炎患者４０例。Ａ组２０例ｐｏＳＡＳＰ４ｇ／ｄ；Ｂ组２０例，其中１４例ｐｏ５ＡＳＡ４ｇ／ｄ，６例直肠栓剂１ｇ／ｄ，疗程均为３０ｄ。结果：Ａ组中４例因不良反应未完成疗程，２例未复查肠镜，余１４例中６例有效（４２．８５％），８例无效。Ｂ组中无１例因不良反应停药，１４例口服５ＡＳＡ患者中１０例有效（７１．４２％）。两组比较，Ｐ＞０．０５；栓剂６例中４例有效（６６．６７％），与Ａ组比较，Ｐ＞０．０５。结论：ＳＡＳＰ与５ＡＳＡ治疗轻、中型溃疡性结肠炎，疗效相近。

OBJECTIVE AND METHOD:In order to compare the efficacy and ADRs of 5 ASA with that of SASP,40 patients with diagnosed ulcerative colitis were allocated to receive oral SAPA 4 g/d for 30 days ( n =20),oral 5 ASA 4 g/d for 30 days( n =14)or 5 ASA suppository 1 g/d for 30 days( n =6).RESULTS:In SASP group:6 patients were response to the treatment (42.85%) and 8 patients didn't,4 patients didn't complete the trial because of ADRs,and 2 patients refused to receive colonoscope diagnose,In 5 ASA treated patients:10 in oral group were effective(71.42%) and 4 in suppository group were effective(66.67%).CONCLUSION:The efficacy of 5 ASA and SASP were similar in treatment of ulcerative colitis but the ADRs of the former are significantly less than that of the later.