舒普深和头孢三嗪治疗肺部感染的研究

A RANDOMIZED STUDY ON THE EFFICACY AND SAFETY OF SULPERAZON IN COMPARISON WITH CEFTRIAXONE IN TREATMENT OF LUNG INFECTIONS

目的：观察舒普深治疗肺部感染的疗效及安全性。方法：肺部感染１２８例随机分为两组：舒普深组６４例，静滴１．０～２．０ｇ，ｂｉｄ；头孢三嗪组６４例，静滴１．０～２．０ｇ，ｂｉｄ，两组均治疗１～２周。结果：舒普深组及头孢三嗪组有效率分别为９３．７％及８９．１％，细菌清除率分别为８９．７％及８３．８％，不良反应发生率分别为６．３％及８．１％。经统计学处理均无显著性差异（Ｐ＞０．０５）。

OBJECTIVE:To evaluate the efficacy and safety of sulperazon in comparison with ceftriaxone in treatment of lung infections.METHODS:128 patients with lung infections were equally divided to receive sulperazon infusion or ceftriaxone infusion in a regimen of 1.0～ 2.0g ,bid for 1～2 weeks.RESULTS:The effective rate,bacterial clearance rate,and ADRs incidence rate of both agents are similar without statistically significant difference( P >0.05).CONCLUSION:From results of this study it can be concluded that sulperazon is an effective and safe drug for treatment of lung infection.