癌痛膏(散)镇痛、消炎作用的临床及实验研究

CLINICAL STUDY AND EXPERIMENT OF THE ANALGESIC AND ANTIPHLOGISTIC ACTIVITIES CANCER PAIN PLASTER(POWDER)

目的：开发一个低毒无成瘾性但有镇痛抗癌作用的中药制剂。方法及结果：临床观察对３６例晚期癌痛患者外敷癌痛膏镇痛有效率９４％，显效率５５．４％。用药半年，无成瘾、无肝肾损伤。动物实验镇痛：膏剂外敷，对抗甲醛引起的疼痛（１０ｍｉｎ）起效，持续１ｈ以上。消肿：对巴豆油致小鼠耳肿胀抑制率３５．５％，虽低于考的松５０．６％，证明对无菌性炎症消肿功效可靠。抑菌试验：显示该药对金葡菌、大肠杆菌、克雷白肺炎杆菌、溶血性链球菌ＭＩＣ均为２．５μｇ／ｍｌ，有抑菌作用。散剂内服镇痛试验：以散剂１．０～２．０ｇ／（ｋｇ·ｄ）动物灌胃给药，连用３～５ｄ，有明显的抗酒石酸锑钾所致小鼠扭体作用。结论：临床、动物试验均证明癌痛膏（散）具有可靠的镇痛。

OBJECTIVE:This study is intended to develop a low toxic and non addictive Chinese traditional medicine preparation that possess of definite analgesic and antitumor activities.METHODS AND RESUETS:1.Clinical observation:Of the 36 advanced cancer patients with acute pain,the effective and significant effective rates of the plaster were found to be 94 and 55.4 percent respectively,and no addictive as well as no injury of the liver or the kidney were found in patients after the application of the plaster for six mouths.2.Animal studies:① Analgesia:The application of the plaster produces quick effectiveness (10 minutes)which lasts more than 60 minutes in pains caused by formaldehyde.② Detumescence:In mouse ototumefaction caused by crouton oil, the inhibitory rate was 35.5%,which lower than that of cortisone (50.6%),it is reliable in relieving aseptic inflammations.③ Bacteriostatic experiments:The MIC of the bactreiostasis of the plaster is 2.5 μg/ml for staphylococci,bacillus coli,klebsialla pneumonia,hemolytic streptococci ,etc.④ Studies on the analgesic effect of the oral powder:The powder,when administered to animals for three to five days at the dosage of 1.0～2.0/(kg·d) ,produces evident effect on abdominal twitch caused by antimony potassium tartrate.CONCLUSION:Both clinical and animal studies show that this carcinoma pain plaster(powder) is effective in relieving pain,extincting inflammation.