长效睾丸酮治疗慢性再生障碍性贫血

CLINICAL OBSERVATION OF THE EFFICACY AND TOXICITY OF LONG ACTING TESTOSTERONE IN TREATMENT OF CHRONIC APLASTIC ANEMIA

的：应用长效睾丸酮（巧理宝），治疗慢性再生障碍性贫血，观察其疗效及肝脏毒性。方法：５６例慢性再生障碍性贫血分为长效睾丸酮治疗组２４例，２５０ｍｇ／次，ｉｍ，２次／周，血红蛋白正常１次／周，１年后，１次／２周。康力龙对照组３２例，疗程１．５～２年。结果：治疗组和对照组有效率分别为７９．１％和７５．０％（Ｐ＞０．０５），而肝脏毒性分别为８．３％和６２．５％（Ｐ＜０．０１）。结论：长效睾丸酮是一种安全、有效的雄激素制剂，且肝功能损害率极低。

OBJECTIVE: To observe the efficacy and hepatic toxicity of long acting testosterone in treatment of chronic aplastic anemia.METHODS:56 patients with chronic aplastic anemia were divided to receive long acting testosterone( n =24)or stanozolol( n =32)for a period of 1.5 to 2 years.RESULTS:The effective rates for active and control groups were 79.1% and 75.0% ( P > 0.05) respectively and their hepatic toxicity were 8.3% and 62.5% respectively.CONCLUSION:Long acting testosterone,triolandren,is a safe and effective agent for treatment of chronic aplastic anemia with a low hepatic toxicity.