首发未药物治疗青少年重性抑郁障碍患者脑三维结构磁共振病例对照研究

Magnetic Resonance Imaging Case Control Study on Brain Three Dimension Structural Abnormalities of First-episode Medication-naive Adolescents with Major Depressive Disorder

目的:探讨首发未药物治疗青少年重性抑郁障碍患者脑灰质体积与正常对照组青少年之间的异同。方法:对18名首发未治疗青少年重性抑郁障碍患者和年龄性别匹配的18名青少年健康对照组进行脑三维结构扫描,对脑灰质体积异常变化应用基于体素的形态测量学分析方法VBM进行分析比较。结果:抑郁组相比对照组VBM灰质形态学体积增加的部位主要在右脑颞上回及双侧颞叶颞中回,尤其是BA22和BA19;抑郁组相比对照组VBM体积减少部位主要位于右脑额叶(BA11,47)、左脑顶叶(BA7,40)和右脑顶叶(BA5),左脑岛叶(BA13)及左脑颞叶(BA13)。结论:抑郁组相比对照组的灰质体积以下降为主,主要在右脑额叶及左脑顶叶、右脑顶叶、左脑岛叶和左脑颞叶。

Objective：To compare the gray matter volume abnormalities on brain three dimension structure of first-episode medication-naive adolescents with major depressive disorder,with normal control group.Methods：18 first episode medication naive adolescents with major depressive disorder and 18 age and sex-matched healthy adolescents were scanned with 3T magnetic resonance imaging;and voxel based morphometry on Statistical Parametrical Mapping was used to analyse the data.The VBM gray matter volume of both groups were compared with two sample t-test.Results：Gray matter volume increased in right superior temporal gyrus and bilateral middle temporal gyrus,especially in BA 22 and BA19,whereas gray matter volume decreased in right frontal lobe（BA11,47）,left parietal lobe（BA 7,BA40）,right parietal lobe（BA 5）,left insular（BA 13） and left temporal lobe（BA 13）.Conclusion：Gray matter volume in MDD group mainly decreases in right frontal lobe（BA11,BA47）,left parietal lobe（BA 7,BA 40）,right parietal lobe（BA 5）,left insular（BA 13）and left temporal lobe（BA 13）.