HBV母婴传播阻断后奶水、脐血、新生儿血清HBV标志物检测分析

The Analysis of Detection of Hepatitis B Markers in Colostrum of Delivery Woman,Umbilical Blood And Serum in Newborns after Blocking Vertical Transmission

目的观察血清HBV标志物的变化,分析产前和产后联合阻断措施对HBsAg(+)、抗HBe(+)、抗HBc(+)孕妇及HBsAg(+)、HBeAg(+)、抗HBc(+)孕妇HBV母婴传播阻断的效果。方法收集2001年至2009年间孕产妇及其所娩新生儿的静脉血、初乳、脐血进行乙肝标志物检测与分析。结果 84例HBsAg(+)、抗HBe(+)、抗HBc(+)产妇初乳中HBsAg(+)检出率26.2%;32例HBsAg(+)、HBeAg(+)、抗HBc(+)产妇初乳HB-sAg(+)检出率93.8%,其中HBeAg(+)检出率56.3%。39例HBsAg(+)、抗HBe(+)、抗HBc(+)产妇所娩新生儿脐血HBsAg(+)检出率25.6%;18例HBsAg(+),HBeAg(+)、抗HBc(+)产妇所生新生儿脐血HBsAg(+)检出率55.6%,其中HBeAg(+)检出率50.0%。88例HBsAg(+)、抗HBe(+)、抗HBc(+)产妇所娩新生儿HBeAg(+)检出率1.1%,抗-HBs(+)检出率为60.2%;38例HBsAg(+)、HBeAg(+)、抗HBc(+)产妇所娩新生儿HBeAg(+)检出率18.4%,抗-HBs(+)检出率为52.6%。结论产前和产后联合阻断措施,能明显阻断HBV母婴传播的发生。

Objective To analyze effect of combined blocking measure at pre-natal and post-natal in blocking vertical transmission of hepatitis B（HBV）,through observing the changes of HBV markers,such as HBsAg,anti-HBs,HBeAg,anti-HBe,anti-HBc.Method Venous blood,colostrum and umbilical blood of pregnant women and newborns from 2001 to 2009 were all collected,tested and analyzed for the HBV markers.Results The detection ratio of HBsAg of colostrum in 84 pregnant women with HBsAg（＋）,anti-HBe（＋）,anti-HBc（＋） was 26.2%.The detection ratio of HBsAg and HBeAg of colostrum in 32 pregnant women with HBsAg（＋）,HBeAg（＋）,anti-HBc（＋） were 93.8% and 56.3% respectively.The detection ratio of HBsAg of umbilical blood in 39 newborns with HBsAg（＋）,anti-HBe（＋）,anti-HBc（＋）,was 25.6%.The detection ratio of HBsAg and HBeAg of umbilical blood in 18 newborns with HBsAg（＋）,HBeAg（＋）,HBcAg（-） were 55.6% and 50.0% respectively.The detection ratio of serum HBeAg and anti-HBsAg in 88 newborns with HBsAg（＋）,anti-HBe（＋）,anti-HBc（＋） were 1.1% and 60.2%.The detection ratio of serum HBeAg and anti-HBsAg in 88 newborns with HBsAg（＋）,HBeAg（＋）,anti-HBc（＋） were 18.4% and 52.6%.Conclusion Combined blocking measure at pre-natal and post-natal could significantly block the HBV vertical transmission.