新生儿唇腭裂危险因素的病例对照研究

A case-control study on risk factors and cleft lip and palate

目的探讨唇腭裂（CLP）的发病原因。方法采用1：1配对的方法，对90例唇腭裂患儿的母亲与非唇腭裂患儿的母亲进行了对照研究，调查范围包括母亲自身危险因素和环境中的危险因素两大方面。结果在所列的7种因素中，有6种因素表现出较高的危险度，依其危险度（OR值）大小排列为：孕期接触工业毒物（9．0），孕期使用某些化学药物（8.0），家中饲养猫、狗等宠物（6．0），父母近亲结婚（6．0），孕期内受病毒感染（4．5）和孕期内喷洒农药除草剂（4．0）。结论孕期内接触有害物质是CLP的重要致病因素。

Objective To study the ralationship between the pregant and environmental factors with risk of CLP. Methods 90 matched pairs were studied with 1: 1 case-control, the CLP Mothers was taken as experiment group while the normal mothers as control group. Results Seven factors which more likely to cause CLP were studied and sit of them were dangerous to the pregnant woman. These are pregant woman touched industrial poisons, took medicines, raised cat:and dog ,etc. Conclusion Pregant woman touched industrial poisons and harmful materials may be the risk factors for high occurrence of CLP.