全麻药物对脑神经毒作用的研究进展

Recend development on toxic effects of general anesthetics on cerebral neurons

从细胞培养、啮齿类动物和非人类灵长类动物的实验研究中得到越来越多的证据：临床常用全麻药物对各期脑神经细胞产生毒性作用,损伤中枢神经系统,特别对处于发育高峰期的大脑影响更大,并影响以后的学习记忆功能.现综述这些事实及目前全麻药物神经毒性作用的机制假设,目的 是让人们对全麻药物毒性作用的最新研究进展有一了解,转变临床麻醉的一些观念.

A growing body of evidence from cells culture, rodents and sub-human primates＇s experimental study suggest that clinical commonly used general anesthetics not only can cause neurotoxicity to neuronal cells of different periods with subsequent central nervous system injury, especially during the brain growth spurt period, but also affect learning and memory function. We review the evidence of neurotoxic effects of anesthetic agents and hypothesis of mechanism, in order to allow people to understand the latest research progress of general anesthetics on toxic effects and change some concept of clinical anesthesia.