小胶质细胞与三磷酸腺苷在疼痛中的作用

Roles of microglia and purinoceptors in pain

大量证据表明,细胞内外三磷酸腺苷（adenosine 5＇-triphosphate,ATP）在疼痛信号转导中起着重要作用.目前研究主要集中在ATP及其受体在慢性疼痛（尤其是神经病理性疼痛）中的作用及其可能机制.机体受到刺激后,激活的小胶质细胞会高表达P2X4受体和其他ATP受体,从而释放脑源性生长因子（brain-derived neurotrophic factor,BDNF）、白介素-1β（interleukin-1β,IL-1β）、白介素-6（interleukin-6,IL-6）、肿瘤坏死因子-α（tumor necrosis factor-a,TNF-α）和一氧化氮（nitric oxide,NO）.了解这些ATP受体的重要作用将为慢性疼痛治疗提供新的策略.

There is a abundant evidence that both extracellular and intracellular ATP have an important role in pain signaling.The focus of attention is now on the possible roles and mechanism of ATP and its receptors in chronic pain states, particularly in neuropathic pain. After the body is stimulated, the activated microglia can over express P2X4R and other ATP receptors, resulting in the release of BDNF ,IL-1β ,TNF-α、IL-6、NO.Understanding the key roles of these ATP receptors may provide new strategies for management of chronic pain states.