钯催化以新型亲电试剂为底物的Suzuki偶联反应性能研究

Study on Suzuki Cross-Coupling Reactions of Novel Electrophilic Substrate with Phenyl Boronic Acid Catalyzed by Palladium

在氩气保护下,室温催化实现了以芳基三氮烯和苯硼酸为底物的Suzuki偶联反应.考察了催化剂、溶剂、两底物物质的量比、催化剂用量等影响反应收率的关键因素,得到了最佳的反应条件,并对底物的普适性进行了研究,结果表明,收率优良.

The Suzuki cross-coupling of aryltriazene with phenylboronic acid catalyzed by transition metal catalyst was achieved.The reaction was performed at room temperature under an argon atmosphere.Catalysts,effect of solvent,aryltriazene/phenylboronic acid ratio and the catalyst loading on the cross-coupling reaction were investigated.The scope of this coupling reaction was explored under optimized reaction conditions.Most of the cross-coupling reactions afforded biaryl products in good to excellent yields.The results indicate that this method has good substrate generality.