阿托伐他汀对老年慢性心力衰竭患者心功能及高敏C反应蛋白水平的影响

Effects of atorvastatin on cardiac function and serum level of hsCRP in elderly patients with chronic heart failure

目的研究阿托伐他汀对老年慢性心力衰竭患者心功能及高敏C反应蛋白水平的影响并探讨其临床意义。方法 80例老年慢性心力衰竭患者随机分为常规组和治疗组,另选健康对照组40例。常规组采用常规抗心力衰竭治疗,治疗组在常规抗心衰基础上加用阿托伐他汀(20 mg/d)。治疗前后采集患者血样标本,测定其血浆高敏C反应蛋白水平。同时行心脏彩色多普勒超声检查,评价心功能变化。结果与对照组比较,心力衰竭患者高敏C反应蛋白水平升高。与常规组比较,治疗组高敏C反应蛋白水平下降更明显(4.08±1.92)mg/L vs(6.34±1.78)mg/L(P<0.01)。治疗组在缩小左心室舒张末径(LVEDD)、增加短轴缩短率(FS)、左心室射血分数(LVEF)方面均优于常规组,LVEDD(44.7±1.02)mm vs(49.8±1.64)mm(P<0.05)、FS(27.85±2.98)%vs(23.63±3.54)%(P<0.01)、LVEF(48.6±8.2)%vs(42.3±5.6)%(P<0.05)。结论阿托伐他汀能降低血浆中C反应蛋白的水平,改善心功能,为心力衰竭的治疗提供了新的思路。

Objective To study the effects of atorvastatin therapy on cardiac function and serum level of hypersensitive C-reactive protein（hsCRP） in elderly patients with chronic heart failure（CHF） and explore its clinical significance.Methods Eighty elderly patients with CHF were randomly assigned to traditional group and treatment group.Control group consisted of 40 healthy people.The patients in the traditional group accepted traditional therapy against heart failure,and atorvastatin treatment（20 mg/d） was added on the base of traditional therapy in treatment group.Before and after therapy,blood samples were collected and serum levels of hsCRP were measured.Left ventricular end-diastolic diameter（LVEDD）,fractional shortening（FS）,and left ventricular ejection fraction（LVEF） were determined by echocardiography.Results Compared with control group,the levels of hsCRP were increased in patients with CHF.Compared with traditional group,patients receiving atorvastatin presented with reduced hsCRP levels（4.08±1.92） mg/L vs（6.34±1.78） mg/L（P0.01）,and improved values of LVEDD（44.7±1.02） mm vs（49.8±1.64） mm（P0.05）,FS（27.85±2.98）% vs（23.63±3.54）%（P0.01） and LVEF（48.6±8.2）% vs（42.3±5.6）%（P0.05）.Conclusion Atorvastatin could reduce the serum level of hsCRP,improve cardiac function,and may represent an additional option for patients with CHF.