药用有机硅化合物的研究进展

Recent Development of Organosilicon Compounds in Drug Discovery

目的综述元素硅在先导化合物优化中的应用及其特点,从而为新药设计提供理论依据。方法对近年来国内外发表的文献进行归纳、总结。结果与结论对现有药物或候选药物进行碳/硅交换是一种寻求新化学实体的有效方法。

OBJECTIVE Review several major features of silicon in optimization of lead compounds,and to provide a theoretical basis for drug design.METHODS Search and summarize the related literatures at home and abroad recently.RESULTS AND CONCLUSION Sila-substitution（C/Si exchange） of existing drugs is an approach to search for new drug-like candidates.