中重度卵巢过度刺激综合征临床特点及治疗

Clinical Analysis of 35 Cases on Moderate and Severe Ovarian Hyperstimulation Syndrome (OHSS)

目的:探讨中重度卵巢过度刺激综合征的临床特点及治疗、预防的方法。方法:回顾性分析我院生殖中心自2007-06～2009-06发生的35例中重度卵巢过度刺激综合征的临床资料。结果:在500个超排卵周期中有35例发生中重度卵巢过度刺激综合征(发生率为7%),临床表现为腹痛、腹胀、恶心、呕吐、体重增加,重度出现胸水、腹水、呼吸困难、血液浓缩,卵巢增大等,经综合治疗,均缓解好转出院,无1例终止妊娠。结论:在实施药物超促排卵过程中要坚持个体化方案,及早预防,对中重度患者严密观察、合理治疗。

Objective：To investigate the characteristics,treatment and prevention of ovarian hyperstimulation syndrome （OHSS）.Methods：From June 2007 to June 2009,35 cases of moderate and severe OHSS inpatients were retrospectively analyzed in the Reproductive Center of the 174th hospital of People＇s Liberation Army.Results：There were 35 moderate and severe OHSS cycles in 500 controlled ovarian super-stimulation cycles,the incident rate was 7%.The main clinical manifestations included abdominal pain、abdominal distension、nausea、weight gain,even hydrothorax 、ascites、dyspnoea、hemoconcentration、increased volume of ovarian,and so on.After the comprehensive therapy,all of them cured,no pregnancy was terminated.Conclusions：Individualization dosage regimen should be taken into the controlled ovarian hyperstimulation （COH） with drugs.The OHSS should be prevented,and the moderate and severe patients should be closely observed and rationally cured.